Dimethyl Sulfoxide
Apexbio Technology LLC SCH 527123 473727-83-2 10mM (in 1mL DMSO)
SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth
Apexbio Technology LLC U-73122 112648-68-7 10mM (in 1mL DMSO)
U-73122 (CAS 112648-68-7) is a phospholipase C (PLC) inhibitor utilized in biomedical research By selectively targeting PLC an enzyme responsible for hydrolyzing phosphatidylinositol 4 5-bisphosphate into intracellular messengers diacylglycerol and inositol-triphosphate U-73122 attenuates downstream signaling events such as protein kinase C activation and intracellular calcium release In vitro U-73122 inhibits recombinant human PLC- 2 with an IC50 of approximately 6 M while minimally affecting PLC- 1 3 and 4 isoforms In animal models U-73122 demonstrates anti-inflammatory properties reducing carrageenan-induced rat paw edema and TPA-induced mouse ear edema
Apexbio Technology LLC CPI-169 1450655-76-1 10mM (in 1mL DMSO)
CPI-169 is a selective small-molecule inhibitor targeting enhancer of zeste homolog 2 (EZH2) a catalytic component of polycomb repressive complex 2 (PRC2) By inhibiting EZH2 enzymatic activity CPI-169 suppresses methylation at histone H3 lysine 27 (H3K27me3) thereby altering chromatin structure and gene expression profiles Pharmacological experiments demonstrate inhibition of EZH2 with subnanomolar IC50 values and cellular studies indicate reductions of H3K27 trimethylation at nanomolar concentrations CPI-169 has been utilized experimentally to investigate EZH2-dependent epigenetic processes cell proliferation apoptosis pathways and therapeutic potential particularly in lymphoma and cancer biology studies employing in vitro and in vivo models
Apexbio Technology LLC Tianeptine sodium(Synonyms: Stablon, Coaxil, Tatinol, Tianeurax, Salymbra, Tianeptine Sodium Salt), 10mM (in 1mL DMSO), CAS: 30123-17-2.
Tianeptine sodium (CAS 30123-17-2) is a small molecule known to selectively facilitate serotonin (5-HT) uptake in both in vitro and in vivo experimental models It exhibits minimal affinity toward various neurotransmitter receptors including serotonin and dopamine receptors (IC 10 M) and does not affect the uptake mechanisms of noradrenaline or dopamine Due to its distinct serotonergic modulation tianeptine sodium is extensively used in neuroscience research particularly in studies investigating the molecular basis and therapeutic potential of antidepressants
Apexbio Technology LLC Orlistat(Synonyms: Xenical, Alli, tetrahydrolipstatin, THL, Roche Xenical, lipase inhibitor, (-)-tetrahydrolipstatin), 10mM (in 1mL DMSO), CAS: 96829-58-2.
Orlistat (CAS 96829-58-2) also referred to as tetrahydrolipstatin is a synthetic derivative of lipstatin originally isolated from Streptomyces toxytricini This small molecule specifically inhibits gastrointestinal lipases particularly pancreatic lipase impeding enzymatic hydrolysis of dietary triglycerides and consequently decreasing intestinal absorption of fat Due to its targeted lipase inhibition Orlistat is widely studied in obesity-related metabolic research and lipid metabolism investigations providing a valuable experimental tool for evaluating effects of reduced dietary fat uptake and downstream physiological responses
Apexbio Technology LLC Irinotecan(Synonyms: CPT-11, Campto, Camptosar, irinotecan hydrochloride, Irinotecan HCl, irinotecan hydrochloride trihydrate), 10mM (in 1mL DMSO), CAS: 97682-44-5.
Irinotecan (CAS 97682-44-5) also known as CPT-11 is an anticancer prodrug that acts as an inhibitor of topoisomerase I Upon enzymatic activation by carboxylesterase (CCE) to its potent metabolite SN-38 it stabilizes the DNA-topoisomerase I cleavable complex causing DNA damage and apoptosis In vitro studies show Irinotecan inhibits various colorectal cancer cell lines including LoVo (IC50 15 8 M) and HT-29 (IC50 5 17 M) Additionally xenograft models such as COLO 320 demonstrate pronounced tumor growth suppression Irinotecan is widely utilized in research to investigate DNA damage mechanisms and therapeutic efficacy in colorectal cancer
Apexbio Technology LLC Brefeldin A(Synonyms: BFA, Ascotoxin, Cyanein, Decumbin, Brefeldin, γ), 10mM (in 1mL DMSO), CAS: 20350-15-6.
Brefeldin A (CAS 20350-15-6) commonly abbreviated as BFA is a small-molecule inhibitor targeting ATPase activity with a reported IC50 of approximately 0 2 M Its primary mechanism of action involves disruption of intracellular vesicle transport by blocking protein trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus and inhibiting GTP/GDP exchange Through these activities BFA reduces ATP-mediated vesicular exocytosis thereby diminishing stimulus-dependent hyperalgesia Additionally it induces endoplasmic reticulum stress and promotes p53 expression in tumor cell models like MCF-7 and HeLa ultimately enhancing apoptosis in colorectal cancer cells (HCT116) BFA is widely employed as a pharmacological tool in cellular biology research to study protein secretion vesicular transport dynamics and ER stress pathways
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 500mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Apexbio Technology LLC UNC1999(Synonyms: UNC-1999, UNC 1999, EZH2 inhibitor UNC1999, EZH2-IN-UNC1999, EZH2-IN3), 10mM (in 1mL DMSO), CAS: 1431612-23-5.
UNC1999 (CAS 1431612-23-5) is a small molecule inhibitor targeting EZH2 and EZH1 enzymes responsible for methylating lysine 27 on histone H3 (H3K27me3) a modification associated with transcriptional suppression It inhibits EZH2 and EZH1 with IC50 values of 2 nM and 45 nM respectively binding at the enzyme s SAM cofactor binding site but not competing with histone substrate UNC1999 reduces cellular H3K27me3 levels (IC50 124 nM) and inhibits proliferation of DLBCL cells harboring EZH2 Y641N mutation (EC50 633 nM) It exhibits oral bioavailability in mouse studies supporting its utility as a research probe for investigating EZH-mediated epigenetic regulation
Apexbio Technology LLC Corticosterone(Synonyms: 17-Deoxycortisol, 11β,21-Dihydroxyprogesterone, Reichstein's Substance B, Kendall's Compound B), 10mM (in 1mL DMSO), CAS: 50-22-6.
Corticosterone (CAS 50-22-6) is an endogenous steroid hormone secreted by the adrenal cortex which exhibits affinity toward both glucocorticoid and mineralocorticoid receptors Its mechanism of action involves serum- and glucocorticoid-inducible kinase (SGK)-mediated phosphorylation of GDP dissociation inhibitor (GDI) at Ser-213 thereby promoting GDI-Rab4 complex assembly This activity enhances Rab4-dependent recycling of AMPA receptors to cortical neuron synapses leading to elevated synaptic excitatory responses Corticosterone thus serves as a useful biochemical tool for investigating stress-related modulation of synaptic transmission and plasticity
Apexbio Technology LLC Bikinin(Synonyms: Bikinin, GSK3 Inhibitor VII, Glycogen Synthase Kinase-3 Inhibitor VII, GSK-3 Inhibitor VII), 10mM (in 1mL DMSO), CAS: 188011-69-0.
Bikinin (CAS 188011-69-0) is a small molecule inhibitor targeting glycogen synthase kinase 3 (GSK3)-like kinases particularly BIN2 thereby activating brassinosteroid (BR) signaling pathways downstream of the BRI1 receptor BR signaling regulates plant developmental processes including stem elongation vascular cell differentiation leaf expansion and stress responses Treatment with Bikinin can phenotypically rescue BR-insensitive mutants in Arabidopsis by restoring BR-dependent gene expression Additionally Bikinin usage promotes xylem cell differentiation in Nicotiana benthamiana leaf disk culture suggesting utility across different biological models
Apexbio Technology LLC UNC0638 1255580-76-7 10mM (in 1mL DMSO)
UNC0638 is a selective inhibitor of histone methyltransferases G9a and GLP enzymes responsible for mono- and dimethylation of histone H3 lysine-9 (H3K9) It inhibits G9a and GLP activity with IC50 values of 15 nM and 19 nM respectively UNC0638 reduces cellular H3K9 dimethylation levels demonstrated in MDA-MB-231 cells with an IC50 of 81 9 nM at 48 hours It has been utilized in models to study epigenetic regulation including neuroendocrine tumor xenografts and hair cell damage induced by aminoglycosides addressing roles of H3K9 methylation in disease pathogenesis and therapeutic responses
Apexbio Technology LLC Etonogestrel(Synonyms: 3-Ketodesogestrel, Implanon, Nexplanon, ORG-3236, 11-Methylenelevonorgestrel), 10mM (in 1mL DMSO), CAS: 54048-10-1.
Etonogestrel (CAS 54048-10-1) is a synthetic steroidal molecule derived as the biologically active metabolite of the progestin desogestrel Structurally it belongs to the 19-nortestosterone class and acts primarily through potent binding and agonist activity at progesterone receptors Through this receptor binding it modulates various physiological processes including ovulation suppression cervical mucus viscosity enhancement and endometrial alteration Etonogestrel serves as a widely researched hormonal contraceptive with applications in reproductive biology studies endocrinological research and pharmaceutical development
Apexbio Technology LLC ML216 1430213-30-1 10mM (in 1mL DMSO)
ML216 (CAS 1430213-30-1) is a small molecule inhibitor targeting Bloom (BLM) helicase a DNA unwinding enzyme essential for homologous recombination-mediated DNA repair ML216 inhibits DNA unwinding activity of full-length BLM (IC50 3 0 M) and a truncated form BLM636-1298 (IC50 0 97 M) displaying sub-micromolar selectivity relative to other helicases such as RECQ1 RECQL5 and bacterial UvrD In cellular assays ML216 selectively suppresses proliferation in BLM-containing fibroblasts increasing sister chromatid exchange frequency consistent with BLM functional deficiency By inhibiting BLM helicase ML216 may sensitize tumor cells to conventional DNA-damaging therapeutics indicating potential application in cancer research and therapy development
Apexbio Technology LLC Cyclo (-RGDfK) 161552-03-0 10mM (in 1mL DMSO)
Cyclo(-RGDfK) is a cyclic pentapeptide that functions as an inhibitor targeting the integrin v 3 Integrins are transmembrane receptors mediating cell adhesion by recognizing specific peptide sequences notably the Arg-Gly-Asp (RGD) motif Integrin v 3 is involved in cell adhesion processes such as angiogenesis tissue remodeling and tumor development and is abundantly expressed on activated endothelial cells and various tumor cells Cyclo(-RGDfK) specifically binds integrin v 3 disrupting integrin-mediated cell attachment Consequently it is frequently utilized in bioengineering applications to modify biomaterial surfaces for enhanced cellular adherence and integration Additionally cyclo(-RGDfK) serves as a targeting ligand in imaging probes aimed at localizing integrin-positive tissues in cancer research